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Muscle Relaxers Side Effects: Identification and Management Strategies

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Muscle Relaxers' Side Effects

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Muscle relaxants are drugs commonly prescribed to alleviate muscle spasms and pain. They are very effective but can also cause unwanted side effects. Understanding and managing these side effects is paramount to using muscle relaxers safely and effectively.

Key Points

  • Muscle relaxants ease muscle spasms and pain by affecting the central nervous system but may cause unwanted side effects.
  • Common muscle relaxer types include benzodiazepines, antispasmodics, and antidepressants, each with different mechanisms and uses.
  • Side effects of muscle relaxers can include drowsiness, dizziness, dry mouth, constipation, and blurred vision, which can affect daily activities.
  • Serious side effects like confusion or respiratory depression can occur, especially with long-term use or high dosages, though they are rare.
  • To manage side effects, stay hydrated, avoid risky activities, adjust medication schedules, and communicate any concerns with your doctor.
  • Muscle relaxers have addiction risks, particularly benzodiazepines, due to their sedative effects and potential for dependence and abuse.
  • Mixing muscle relaxers with alcohol, opioids, or other depressants can dangerously enhance sedative effects and increase overdose risks.

How Muscle Relaxers Work

Muscle relaxers work on the central nervous system or the muscle cells.[1] They reduce the signals from your brain to your muscles or directly act on muscle cells. The result is the relaxing and loosening of the affected muscle groups. Muscle relaxers are commonly prescribed to relieve conditions like back pain, neck pain, muscle injuries, and neurological disorders that cause muscle cramping.

Types of Muscle Relaxers

There are a few different types of muscle relaxers that your doctor may prescribe to you. The most common categories include:[2]

  • Benzodiazepines: Drugs like diazepam (or Valium) and carisoprodol (or Soma) work by enhancing the effects of GABA in your brain to induce muscle relaxation. These muscle relaxers tend to have a higher potential for dependence and abuse.
  • Centrally acting muscle relaxants: Some commonly prescribed muscle relaxers include cyclobenzaprine (or Flexeril) and tizanidine (or Zanaflex), which directly target the central nervous system and block the signals that cause muscle spasms.
  • Antispasmodic agents: Drugs like baclofen and dantrolene work by interrupting the neuromuscular transmission process. They are frequently used for conditions like multiple sclerosis or spinal cord injuries.
  • Antidepressants: Certain antidepressants like cyclobenzaprine and orphenadrine can have mild muscle relaxant properties. It should be noted, however, that muscle relaxation is not the primary intended use for these drugs.

Depending on your condition, your doctor will evaluate the potential benefits and risks of each type of muscle relaxer and prescribe the best option for you. 

Common Side Effects of Muscle Relaxers

Common Side Effects of Muscle Relaxers

It’s important to be aware of the potential side effects that can occur when you’re taking muscle relaxants. Some of the common side effects you may experience are:[3]

  • Drowsiness:  Muscle relaxants have a soothing effect that can make you feel very tired, especially when you start taking the medication. This can impair your ability to drive or safely perform various tasks.
  • Dizziness: The central nervous system effects of muscle relaxants can disrupt your balance and coordination. This may increase your risk of falls or accidents.
  • Dry mouth: Many muscle relaxants can cause your mouth and throat to feel dry and uncomfortable.
  • Constipation: These drugs can slow down your digestive system. This can lead to difficulty with bowel movements.
  • Blurred vision: Some muscle relaxants may temporarily affect your eyesight.

More serious side effects like confusion, hallucinations, or even respiratory depression may occur, particularly with long-term use or higher dosages. This, however, is rare, though you should always be monitoring yourself for any unusual feelings while taking muscle relaxers or any medication.

How to Manage Muscle Relaxers Side Effects

Here are a few things you can do to help alleviate the potential side effects of muscle relaxers:

Get the Help You Need

Struggling with substance abuse, particularly with highly addictive prescription drugs like muscle relaxers, is a common challenge. You don’t have to confront this struggle by yourself. Many treatment centers can provide the support you need to overcome addiction and reclaim a fulfilling life. Seek the assistance you need without delay.

Take the first step toward recovery

Frequently Asked Questions

Are muscle relaxers addictive?

Many muscle relaxers carry a risk of addiction. This is because they work by depressing the central nervous system, which can produce a euphoric, calming effect similar to that of opioid painkillers or alcohol. The benzodiazepine class of muscle relaxers, like diazepam (also known as Valium), are classified as Schedule IV controlled substances due to their high potential for abuse and dependence. Even non-benzodiazepine muscle relaxers like cyclobenzaprine, which are not federally scheduled, can be habit-forming as the brain and body can develop a tolerance to the drug over time.

Using muscle relaxers over the long term, taking them in ways other than prescribed, or combining them with other central nervous system depressants like alcohol or opioids greatly increases their addictive potential. Abrupt discontinuation of these drugs can also cause withdrawal symptoms. This is why taking muscle relaxers exactly as your doctor directs is crucial.

What should you do if you experience extreme side effects?

If you experience extreme or concerning side effects while taking muscle relaxers, take the following steps immediately.

  • Contact your healthcare provider: Explain the symptoms you are having. Your doctor may need to adjust your dosage or switch you to a different muscle relaxer medication.
  • Seek emergency medical attention (if needed): Severe side effects like respiratory depression require immediate treatment. Do not hesitate to call 911 or go to the nearest emergency room if needed.
  • Avoid driving: The sedative effects of muscle relaxers can impair coordination and judgment, putting you at risk of accidents. Have someone else drive you to the doctor or hospital.
  • Provide detailed information to your healthcare team: Be sure to let the doctors and nurses know exactly which muscle relaxer you were taking when you started experiencing the side effects and any other medications you currently use.
What happens if you mix muscle relaxers and other medications or supplements?

Mixing muscle relaxers with other medications can be extremely dangerous and lead to extremely dangerous side effects.[7] Here’s a rundown of the risks:

  • Mixing muscle relaxers with other central nervous system depressants like opioid painkillers, benzodiazepines, or barbiturates can dramatically enhance the sedative and respiratory-depressing effects. This substantially raises the risk of overdose.
  • Taking muscle relaxers along with certain antibiotics, antifungals, or antidepressants may alter the way the body metabolizes the medications.
What happens if you mix muscle relaxers and alcohol?

Alcohol is also a central nervous system depressant. Combining alcohol with muscle relaxers may intensify the sedative, dizzying, and coordination-impairing side effects.[8] This combination significantly increases the risk of respiratory depression, blackouts, and coma, especially at higher doses. Mixing can also exacerbate issues like constipation and dry mouth. Be safe and avoid drinking alcohol while you’re using muscle relaxers.

Can you mix muscle relaxers and over-the-counter drugs like Ibuprofen?

Mixing muscle relaxers and Ibuprofen is generally considered to be safe.[9] There are, however, are important factors to keep in mind:

  • Dosage: Follow the recommended dosages for both muscle relaxers and Ibuprofen. Ensure you’re not exceeding the maximum dosage for either medication.
  • Interactions: Ibuprofen is a non-steroidal anti-inflammatory drug, and muscle relaxers are typically prescribed for muscle spasms. That said, there is a potential for interactions. Muscle relaxers can have sedative effects, so combining them with other medications should be done with extra caution and under the direction of a medical professional.
  • Side effects: Both of these medications can have side effects. Ibuprofen can cause gastrointestinal issues, and muscle relaxers might lead to drowsiness or dizziness. Monitor yourself for any adverse effects and cease taking Ibuprofen if you experience any.

[1]Holland, K. (2023, March 22). Muscle relaxers: Types, uses, and side effects. Medical News Today. https://www.medicalnewstoday.com/articles/muscle-relaxers

[2][8]C. C. medical. (2024c, August 2). Muscle Relaxers. Cleveland Clinic. https://my.clevelandclinic.org/health/treatments/24686-muscle-relaxers

[3]Spine-Health Editorial Team. (2023, May 17). Side effects and risks of muscle relaxers. Spine-Health. https://www.spine-health.com/treatment/pain-medication/side-effects-and-risks-muscle-relaxers#footnote11

[4]National Institute of Dental and Craniofacial Research. (n.d.). Dry mouth. National Institutes of Health. https://www.nidcr.nih.gov/health-info/dry-mouth

[5][6]Centers for Disease Control and Prevention. (n.d.). Medication safety. U.S. Department of Health and Human Services. https://www.cdc.gov/medication-safety/about/index.html

[7][9]Dawwas, G. K., Hennessy, S., Brensinger, C. M., Acton, E. K., Bilker, W. B., Chung, S., Dublin, S., Horn, J. R., Manis, M. M., Miano, T. A., Oslin, D. W., Pham Nguyen, T. P., Soprano, S. E., Wiebe, D. J., & Leonard, C. E. (2022, April). Signals of muscle relaxant drug interactions associated with unintentional traumatic injury: A population-based screening study. CNS drugs. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9375100/

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